The Hallucinogenic Way of Dying

Almost as soon as Dr. Charles Grob secured approval to study the effects of psilocybin on Stage IV cancer patients, he faced another challenge, one nearly as formidable: recruiting 12 participants. Unlike so many other experiments in radical cancer treatment, Grob’s does not offer a cure; he merely hopes to find that psilocybin, the most potent of the many compounds in psychedelic mushrooms, ameliorates a dying person’s fear of death. The study targets patients relegated to “palliative” treatment, people with metastatic cancer for whom there is no reasonable hope for remission. It is a segment of the population, says the National Cancer Policy Board of the Institute of Medicine ? which put out a call in 2001 for “novel” approaches to palliative treatment ? largely ignored by medical science.

Artificial Prions Created

The culprit behind mad cow disease, a.k.a. bovine spongiform encephalopathy, is the most infamous mammalian form of prions. Prions are misfolded proteins that are capable of growing, replicating, and being passed on to daughter cells – that is, they are by themselves heritable. Beyond their disease manifestation, prions also occur naturally in some organisms (such as yeast) and may play important roles in their growth and development. Now, Osherovich and colleagues have identified the amino acid sequences that allow prions to aggregate and replicate – and thereby pass through generations of cells – and prove this by designing an artificial yeast prion that does not exist in nature.

Student Builds Micro Biosensor Chip To Move DNA Molecules

A Johns Hopkins undergraduate has constructed a new type of microchip that can move and isolate DNA and protein molecules. He believes that by linking the chip with analysis equipment, a user could identify medical ailments, monitor a patient’s health or detect viruses and other biohazards before they spread.