Herpes viruses, though not life-threatening, are usually considered to be embarrassing and annoying. Researchers at the LSU School of Veterinary Medicine, however, are using the virus to potentially fight breast cancer, which, according to the American Cancer Society, is the most common cancer among women.
In fact, excluding cancers of the skin, breast cancer accounts for nearly one in three cancers diagnosed in U.S. women.
“Our immune systems are engineered to fight cancer,” said Dr. Konstantin “Gus” Kousoulas, professor of virology in the Department of Pathobiological Sciences and director of the Division of Biotechnology & Molecular Medicine. “The human body’s T-cells belong to a group of white blood cells and play a central role in immunity. However, cancer cells cause the T-cells to essentially fall asleep.
“The tumor emits signals to down-regulate the T-cells. Our herpes virus can be engineered to awaken those cells and modulate the immune system so that it recognizes the tumor cells and destroys them.”
The herpes virus was engineered to selectively replicate in cancer cells; it does not affect normal cells.
“Herpes virus replicate cells on their own,” said Kousoulas. “Cold sores are caused when the herpes virus replicates and kills normal cells; the cold sore is made up of the dead cells. Our herpes virus has been engineered to only replicate and destroy cancer cells, thus killing the tumor. Patients would not contract the herpes virus itself.”
Science Daily