Finnish patient gets new jaw from own stem cells

Scientists in Finland said they had replaced a 65-year-old patient’s upper jaw with a bone transplant cultivated from stem cells isolated from his own fatty tissue and grown inside his abdomen.

Researchers said on Friday the breakthrough opened up new ways to treat severe tissue damage and made the prospect of custom-made living spares parts for humans a step closer to reality.

“There have been a couple of similar-sounding procedures before, but these didn’t use the patient’s own stem cells that were first cultured and expanded in laboratory and differentiated into bone tissue,” said Riitta Suuronen of the Regea Institute of Regenerative Medicine, part of the University of Tampere.

Reuters via Boing Boing

Marijuana Smokers Face Rapid Lung Destruction — As Much As 20 Years Ahead Of Tobacco Smokers

A new study finds that the development of bullous lung disease occurs in marijuana smokers approximately 20 years earlier than tobacco smokers.

A condition often caused by exposure to toxic chemicals or long-term exposure to tobacco smoke, bullous lung disease (also known as bullae) is a condition where air trapped in the lungs causes obstruction to breathing and eventual destruction of the lungs.

At present, about 10% of young adults and 1% of the adult population smoke marijuana regularly. Researchers find that the mean age of marijuana-smoking patients with lung problems was 41, as opposed to the average age of 65 years for tobacco-smoking patients.

The study “Bullous Lung Disease due to Marijuana” also finds that the bullous lung disease can easily go undetected as patients suffering from the disease may show normal chest X-rays and lung functions. High-resolution CT scans revealed severe asymmetrical, variably sized bullae in the patients studied. However, chest X-rays and lung functions were normal in half of them.

Science Daily

Great apes endangered by human viruses

A new study published in the journal Current Biology by researchers of the Robert Koch Institute (Berlin), the Max Planck Institute for Evolutionary Anthropology (Leipzig) and the Centre Suisse des Recherches Scientifiques (Ivory Coast) confirms the disease threat, finding the first direct evidence of virus transmission from humans to wild apes. The study also showed however that research and tourism projects strongly suppressed the poaching of chimpanzees. This protective effect outweighed the substantial chimpanzee mortality caused by human disease introduction.

EurekAlert!

Reversal Of Alzheimer’s Symptoms Within Minutes In Human Study

An extraordinary new scientific study, which for the first time documents marked improvement in Alzheimer’s disease within minutes of administration of a therapeutic molecule, has just been published in the Journal of Neuroinflammation.

This new study highlights the importance of certain soluble proteins, called cytokines, in Alzheimer’s disease. The study focuses on one of these cytokines, tumor necrosis factor-alpha(TNF), a critical component of the brain’s immune system. Normally, TNF finely regulates the transmission of neural impulses in the brain. The authors hypothesized that elevated levels of TNF in Alzheimer’s disease interfere with this regulation. To reduce elevated TNF, the authors gave patients an injection of an anti-TNF therapeutic called etanercept. Excess TNF-alpha has been documented in the cerebrospinal fluid of patients with Alzheimer’s.

The new study documents a dramatic and unprecedented therapeutic effect in an Alzheimer’s patient: improvement within minutes following delivery of perispinal etanercept, which is etanercept given by injection in the spine. Etanercept (trade name Enbrel) binds and inactivates excess TNF. Etanercept is FDA approved to treat a number of immune-mediated disorders and is used off label in the study.

Science Daily

Scientists Restore Walking In Mice After Spinal Cord Injury

Spinal cord damage blocks the routes that the brain uses to send messages to the nerve cells that control walking. Until now, doctors believed that the only way for injured patients to walk again was to re-grow the long nerve highways that link the brain and base of the spinal cord. For the first time, a UCLA study shows that the central nervous system can reorganize itself and follow new pathways to restore the cellular communication required for movement.

The discovery could lead to new therapies for the estimated 250,000 Americans who suffer from traumatic spinal cord injuries. An additional 10,000 cases occur each year, according to the Christopher and Dana Reeve Foundation, which helped fund the UCLA study.

“Imagine the long nerve fibers that run between the cells in the brain and lower spinal cord as major freeways,” explained Dr. Michael Sofroniew, lead author and professor of neurobiology at the David Geffen School of Medicine at UCLA. “When there’s a traffic accident on the freeway, what do drivers do? They take shorter surface streets. These detours aren’t as fast or direct, but still allow drivers to reach their destination.

“We saw something similar in our research,” he added. “When spinal cord damage blocked direct signals from the brain, under certain conditions the messages were able to make detours around the injury. The message would follow a series of shorter connections to deliver the brain’s command to move the legs.”

Science Daily

Sea Cucumber Protein Used To Inhibit Development Of Malaria Parasite

Scientists have genetically engineered a mosquito to release a sea-cucumber protein into its gut which impairs the development of malaria parasites, according to new research. Researchers say this development is a step towards developing future methods of preventing the transmission of malaria.

Malaria is caused by parasites whose lives begin in the bodies of mosquitoes. When mosquitoes feed on the blood of an infected human, the malaria parasites undergo complex development in the insect’s gut. The new study has focused on disrupting this growth and development with a lethal protein, CEL-III, found in sea cucumbers, to prevent the mosquito from passing on the parasite.

Science Daily via Kurzweil AI

‘Golden Bullet’ Shows Promise For Killing Common Parasite

Researchers in Australia report development of a new type of gold nanoparticle that destroys the parasite responsible for toxoplasmosis, a potentially serious disease acquired by handling the feces of infected cats or eating undercooked meat. Their so-called “golden bullet” could provide a safer, more effective alternative for treating the disease than conventional drug therapy, they say.

Science Daily

Psychedelic Healing?

Mind-altering psychedelics are back—but this time they are being explored in labs for their therapeutic applications rather than being used illegally. Studies are looking at these hallucinogens to treat a number of otherwise intractable psychiatric disorders, including chronic depression, post-traumatic stress disorder, and drug or alcohol dependency.

The past 15 years have seen a quiet resurgence of psychedelic drug research as scientists have come to recognize the long-underappreciated potential of these drugs. In the past few years, a growing number of studies using human volunteers have begun to explore the possible therapeutic benefits of drugs such as LSD, psilocybin, DMT, MDMA, ibogaine and ketamine.

Much remains unclear about the precise neural mechanisms governing how these drugs produce their mind-bending results, but they often produce somewhat similar psychoactive effects that make them potential therapeutic tools. Though still in their preliminary stages, studies in humans suggest that the day when people can schedule a psychedelic session with their therapist to overcome a serious psychiatric problem may not be that far off.

Scientific American via Dose Nation

Cannabis could help stop breast cancer

A compound found in cannabis may prevent breast cancer spreading to other parts of the body, scientists believe.

Experts hope that cannabidiol, also known as CBD, could be a realistic alternative to chemotherapy.

However, the study carried out by the California Pacific Medical Centre Research Institute does not advocate marijuana use among cancer patients.

It said it was unlikely that the right concentrations of CBD could be achieved through smoking cannabis.

CBD fights the disease by stopping the activity of a gene called Id-1, which is believed to be responsible for the spread of cancer cells from the site of the original tumour – a process known as metastasis.

The study found CBD had this affect on breast cancer cells in a laboratory.

Researchers are now optimistic that the compound can become an effective – and non-toxic – alternative to chemotherapy.

Stem Cell Breakthrough Is Like ‘Turning Lead Into Gold’

In an unprecedented feat of biological alchemy, researchers have turned human skin cells into stem cells that hold the same medical promise as the controversial embryonic stem cells.

Scientists believe stem cell research will be able to cure numerous diseases and regenerate failing bodies. The new technique, however, doesn’t require the destruction of embryos, or use human eggs or cloning. Thus, it sweeps aside the ethical objections to stem-cell research.

Even in a field accustomed to breathless proclamations of breakthroughs, the research—published Tuesday in two papers appearing in the journals Cell and Science—has provoked wonder among many scientists. They say the advance is more significant to medical research than last week’s announcement that scientists had cloned the first monkey embryo.

Wired

Britain’s first drug ‘shooting galleries’ hailed a success

A trial scheme which set up “shooting galleries” in three cities, enabling heroin users to obtain drugs and inject them under supervision, has dramatically cut crime rates and stopped addicts buying their supplies on the streets.

Yesterday’s preliminary results from the £2.5m pilot project sent a ripple of excitement through the treatment community, because long-term heroin users are among the hardest addicts to treat. They lead chaotic lives, often robbing and stealing to fund their habits. According to official figures, 10 per cent of drug addicts commit 75 per cent of the acquisitive crimes in the Britain. But the number of offences committed by the heroin addicts taking part in the shooting gallery scheme fell from an average of 40 each per month before they were admitted to “about half a dozen a month” after six months of intensive therapy, according to Professor John Strang, the head of the National Addiction Centre at the Maudsley Hospital, who is leading the study.

Instead of buying street heroin every day, the 150 volunteers are now buying it only four or five times a month on average – while a third of them have completely stopped “scoring” the drug on the streets.

The Independent

Paralysed man’s mind is ‘read’

Electrodes have been implanted in the brain of Eric Ramsay, who has been “locked in” – conscious but paralysed – since a car crash eight years ago.

These have been recording pulses in areas of the brain involved in speech.

Now, New Scientist magazine reports, they are to use the signals he generates to drive speech software.

Although the data is still being analysed, researchers at Boston University believe they can correctly identify the sound Mr Ramsay’s brain is imagining some 80% of the time.

In the next few weeks, a computer will start the task of translating his thoughts into sounds.

BBC News via Kurzweil AI

Herpes Virus Can Be Used As Nanomachines For Cancer Treatment

Herpes viruses, though not life-threatening, are usually considered to be embarrassing and annoying. Researchers at the LSU School of Veterinary Medicine, however, are using the virus to potentially fight breast cancer, which, according to the American Cancer Society, is the most common cancer among women.

In fact, excluding cancers of the skin, breast cancer accounts for nearly one in three cancers diagnosed in U.S. women.

“Our immune systems are engineered to fight cancer,” said Dr. Konstantin “Gus” Kousoulas, professor of virology in the Department of Pathobiological Sciences and director of the Division of Biotechnology & Molecular Medicine. “The human body’s T-cells belong to a group of white blood cells and play a central role in immunity. However, cancer cells cause the T-cells to essentially fall asleep.

“The tumor emits signals to down-regulate the T-cells. Our herpes virus can be engineered to awaken those cells and modulate the immune system so that it recognizes the tumor cells and destroys them.”

The herpes virus was engineered to selectively replicate in cancer cells; it does not affect normal cells.

“Herpes virus replicate cells on their own,” said Kousoulas. “Cold sores are caused when the herpes virus replicates and kills normal cells; the cold sore is made up of the dead cells. Our herpes virus has been engineered to only replicate and destroy cancer cells, thus killing the tumor. Patients would not contract the herpes virus itself.”

Science Daily

Trained Rats Sniff Out Explosives and Diseases

ratAccording to the International Campaign to Ban Landmines, an estimated 15-20,000 people are killed by landmines each year. Detecting those mines—without setting them off—is a dilemma that faces many post-conflict regions of the world. But Bart Weetjens may have found a six-pound solution to the problem: the African giant pouched rat. Working for APOPO, a Belgian organization founded to explore the idea, Weetjens has successfully trained rats to locate land mines by smell. The animals have also been trained to identify tuberculosis from samples, a development that may prove equally promising.

How did he come up with the idea of using rats for these detection problems? In a Skype interview from his office in Tanzania, Weetjens confessed that he’s always been interested in helping Africa but was initially stalled for solutions. “I wanted to do something in the real world, something appropriate to the environment,” he told Ars.

Ars Technica